Declaration of interest

Region Syddanmark

Ph.d. & forskning

Predicting disease course and improving diagnosis of patients with inflammatory bowel disease (IBD); The Nordic IBD treatment strategy trial (NORDTREAT)

Aim of the Ph.D.

The overall aim is to improve Inflammatory bowel disease (IBD) patients' prognosis and quality of life by introducing a novel predictive protein signature.

IBD is a disease entity of unknown origin, characterized by a chronic inflammation in the gastrointestinal tract. IBD is increasing, especially among teenagers, and today 0.5-1% of the Nordic population is affected.

The disease course varies from an indolent course to an aggressive, treatment refractory disease, with need of repeated hospital admissions, surgery and increased risk of comorbidity including cancer. Thus, IBD have severe consequences for many affected individuals, including life-long medication, hospitalizations, recurring sick-leaves, and surgical interventions. The extensive heterogeneity among IBD patients, specifically inter-individual variability with respect to disease progression, is a major clinical challenge. Current IBD treatment is expensive and lack therapeutic precision, which reduces efficacy and safety and increases the risk of disease progression throughout life.

In this project, our aim is to selectively identify patients with a poor prognosis based on a novel objective protein signature, recently identified by members of the NORDTREAT team, and adapt the treatment in these patients to minimize disease-induced damage on the gastrointestinal tract and to improve long-term disease outcomes. By implementing this personalized medicine strategy, NORDTREAT will reduce societal costs and improve quality of care for patients with IBD.

Patients are recruited from 4 Nordic countries. In Denmark, patients will be recruited from Odense-Svendborg University Hospital and University Hospital of Southern Jutland, Åbenrå. This PhD will be responsible for recruiting patients in Åbenrå. The PhD student will be involved in describing the PhD study protocol together with the Danish NORDTREAT team.

The research team
. You will be a member of a small, ambitious, research team with various backgrounds (molecular biology, doctors, nurse and health research). You will be in close contact with other Ph.D. students.

. Contact: Signe Bek Sørensen, postdoc,, +45 2938 5683 (study coordinator). Vibeke Andersen, professor, Focused Research Unit for Molecular Diagnostics and Clinical Research, University Hospital of Southern Denmark, Åbenrå, +45 2115 7790, (main supervisor), Jens Kjeldsen, professor, Odense University Hospital, Odense.

Practical Information
. A PhD student with interest for clinical study coordination is preferred (e.g. Molecular Science, Medicine or Human Biology). You will need to speak Danish. One year of wage is already paid by NORDFORSK. You will be involved in writing the protocol, applying for the rest of the economy (the region, the faculty, and the hospital). The study will be performed at University Hospital of Southern Denmark, 6200 Aabenraa, in close contact with SDU/OUH. Only an applicant with at least one published work is accepted as a Ph.D. student. Children day care and housing facilities are present near the hospital.

Deadline for the application: 15.11. The interview will take place 22.11 at the University Hospital of Southern Denmark, Åbenrå.

Salary. The PhD programme will be carried out in accordance with Faculty regulations and the Danish Ministerial Order on the PhD Programme at the Universities (PhD order). The terms of employment as a salaried PhD Research Fellow are stated in the Agreement between the Ministry of Finance and the Danish Confederation of Professional Associations (AC).

Applications must include:

  •  A letter stating the interest, motivation and qualifications for the project (max. 2 pages)
  •  Detailed CV, including personal contact information
  •  Certified copy of Diploma (Master’s degree in a relevant field)

Additional information may be requested and the application process may include an interview before final decision is made. Successful candidates will be asked to send an application to the PhD Secretariat, Faculty of Health Sciences, to be enrolled as PhD students. Incomplete applications and applications received after the deadline will not be considered. All interested and qualified persons are encouraged to apply, regardless of age, gender, religious affiliation or ethnic background.

Ansøgningsfrist: snarest muligt
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