Postdoc in Medicinal Chemistry - DTU Chemistry

Design and synthesis of proteolysis-targeted chimeras for mitogen-activated protein kinases (MAPKs). The project includes design, synthesis and characterize putative degraders based on known MAPK ligands. Effective and selective degraders will be further characterized in relevant disease models.
If you are establishing your career as a scientist and you are looking for the best possible foundation for fulfilling your dreams and ambitions, it is right here in front of you. At DTU Chemistry you will break new ground at the absolute forefront of what is possible within chemical biology and medicinal chemistry.

A one-and-a-half-year postdoc position is available within the Department of Chemistry, DTU. In this position you will perform research related to design and synthesis of proteolysis-targeted chimeras (PROTACs) for mitogen-activated protein kinases (MAPKs). The project is a collaboration with a research group at CSIC in Madrid and is funded by the Independent Research Fund Denmark. The position is within the research group in Chemical Biology and Medicinal Chemistry headed by Prof. Mads H. Clausen.

Responsibilities and qualifications
The position offers an opportunity to work with a dynamic and multi-disciplinary project. You will carry out research in a team focused on developing targeted degraders of disease-related macromolecules. The research project will provide opportunities to design, synthesis, and characterize putative degraders based on known MAPK ligands. Effective and selective degraders will be further characterized in relevant disease models in vitro and in vivo. In this position you will have opportunities to work with undergraduate and graduate students as well.

You have an interest in medicinal chemistry and a desire to work in an interdisciplinary environment.

We are looking for a profile witha documented track record in synthetic chemistry and a desire to work with Medicinal Chemistry. You show a strong commitment to research, and you are enthusiastic about working with research students. You like to drive research and take ownership of your project and direction but also thrive in a team working closely together and feeding off each other’s ideas.

As a formal qualification, you must hold a PhD degree (or equivalent) in chemistry and a strong theoretical and experimental background in medicinal chemistry.

Open-minded knowledge sharing and constructive teamwork are key to the success of the project in total. Additionally, your CV comprises:

• A thorough interest in medicinal chemistry and chemical biology.
• Experience with design and synthesis of bioactive small molecules.
• A track record of communicating research results.

In the assessment of the candidates, consideration will be given to:

• Relevance of education and previous experience.
• Passion for research and scientific discoveries.
• Proficiency in written and spoken English and good communication skills.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and terms of employment
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations (AC). The allowance will be agreed upon with the relevant union.

The period of employment is 1.5 years. The starting date is April 1, 2025 (or according to mutual agreement). The position is a full-time position.

You can read more about career paths at DTU here.
Further information
Further information may be obtained from Prof. Mads H. Clausen, Department of Chemistry, [email protected]

You can read more about DTU Chemistry at www.kemi.dtu.dk and more about the research group at www.kemi.dtu.dk/mhc

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.

Application procedure
Your complete online application must be submitted no later than 23 February 2025 (23:59 Danish time).

Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in a single PDF file. The file must include:

• Application (cover letter)
• CV including a list of publications and contact information for at least two references
• Academic Diplomas (MSc/PhD – in English)
• List of publications

Applications received after the deadline will not be considered.

All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. As DTU works with research in critical technology, which is subject to special rules for security and export control, open-source background checks may be conducted on qualified candidates for the position.

Technology for people
DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.

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